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Caractérisation de l'architecture tridimensionnelle du tissu trabéculaire in vitro et in vivo par IRM

Abstract : There are two types of bone tissues, cortical and trabecular. Cortical bone is a compact tissue constituting bone envelope. Trabecular bone is a porous tissue consisting in a lattice of trabeculae (around 100 µm width) delimiting an interconnected space filled with marrow. Early detection of osteoporosis is possible in this tissue. As it is a non invasive method able to provide 3D images with isotropic resolution, MRI is of interest for trabecular bone architecture studies. However MRI resolution is at present limited to about 100 µm, i.e. comparable to trabecular thickness. This work had the three following aims. The first one was to develop methods for the assessment of structure parameters in order to characterize trabecular architecture on 3D images with a spatial resolution of a few tens of microns. The second one was to use them to estimate the accuracy of 8.5 T MR microscopy trabecular structure representation by reference to a « Gold Standard » technique: synchrotron radiation X-ray microtomography. This was performed in vitro on 29 calcaneus samples. Architecture parameters computed on common regions of interest (ROI) were compared between the two modalities. These ROIs were previously automatically matched. It was shown that the trabecular structure general organization was reliably represented by MR (66 µm)3 resolution images. On the other hand, bone volume fraction evaluation, although precise, was significantly biased. Several hypothesis were checked to explain this bias. Finally, the third one was to establish an in vivo protocol. (78 µm)3 resolution MR images of the human finger were acquired at 7 T. These images were used to develop an automatic 3D method to delineate trabecular and cortical regions. Computation of architecture parameters was also performed on the trabecular region.
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https://tel.archives-ouvertes.fr/tel-00006073
Contributor : David Last <>
Submitted on : Wednesday, May 12, 2004 - 11:06:09 AM
Last modification on : Friday, October 23, 2020 - 4:55:11 PM
Long-term archiving on: : Friday, April 2, 2010 - 8:49:56 PM

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David Last. Caractérisation de l'architecture tridimensionnelle du tissu trabéculaire in vitro et in vivo par IRM. Physique [physics]. Université Paris Sud - Paris XI, 2003. Français. ⟨tel-00006073⟩

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