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Validation de la plate-forme de simulation GATE en Tomographie d'Emission Monophotonique et application au développement d'un algorithme de reconstruction 3D complète

Abstract : Monte Carlo simulations are currently considered in nuclear medical imaging as a powerful tool to design and optimize detection systems, and also to assess reconstruction algorithms and correction methods for degrading physical effects. Among the many simulators available, none of them is considered as a standard in nuclear medical imaging: this fact has motivated the development of a new generic Monte Carlo simulation platform (GATE), based on GEANT4 and dedicated to SPECT/PET applications. We participated during this thesis to the development of the GATE platform within an international collaboration. GATE was validated in SPECT by modeling two gamma cameras characterized by a different geometry, one dedicated to small animal imaging and the other used in a clinical context (Philips AXIS), and by comparing the results obtained with GATE simulations with experimental data. The simulation results reproduce accurately the measured performances of both gamma cameras. The GATE platform was then used to develop a new 3D reconstruction method (F3DMC) which consists in computing with Monte Carlo simulation the transition matrix used in an iterative reconstruction algorithm (in this cas, ML-EM), including within the transition matrix the main physical effects degrading the image formation process. The results obtained with the F3DMC method were compared to the results obtained with three other more conventional methods (FBP, MLEM, MLEMC) for different phantoms. The results of this study show that F3DMC allows to improve the reconstruction efficiency, the spatial resolution and the signal to noise ratio with a satisfactory quantification of the images. These results should be confirmed by performing clinical experiments and open the door to a unified reconstruction method, which could be applied in SPECT but also in PET.
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https://tel.archives-ouvertes.fr/tel-00005443
Contributor : Delphine Lazaro <>
Submitted on : Tuesday, March 23, 2004 - 3:21:56 PM
Last modification on : Thursday, February 25, 2021 - 10:58:20 AM
Long-term archiving on: : Friday, April 2, 2010 - 8:20:34 PM

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  • HAL Id : tel-00005443, version 1

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Delphine Lazaro. Validation de la plate-forme de simulation GATE en Tomographie d'Emission Monophotonique et application au développement d'un algorithme de reconstruction 3D complète. Biophysique [physics.bio-ph]. Université Blaise Pascal - Clermont-Ferrand II, 2003. Français. ⟨tel-00005443⟩

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