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Synthèse et caractérisation de nouveaux copolymères potentiellement autoassociatifs

Abstract : The aim of this study is to synthesize new auto-associative copolymers in order to encapsulate a protein in water. These copolymers have to be biocompatible and bioassimilable for a possible biomedical application. Further more, they have to be amphiphilic. This document aims at describing the synthesis of amphiphilic bloc copolymers. The association of the hydrophobic blocs of the copolymer in water should entail to core-shell particle formation in aqueous emulsion. The hydrophobic part of the copolymers is a polylactide synthesized by ring opening polymerization of the L-lactide. The hydrophilic bloc is a poly(glutamic acid) peptide synthesized in two steps. We first synthesized a poly(benzyl glutamate) bloc by ring opening polymerization of a Leuch's anhydride, the N-carboxyanhydride of benzyl L-glutamate. Then we unprotect the acidic functions of this poly(benzyl glutamate), still hydrophobic polymer to yield the hydrophilic poly(glutamic acid). The architecture of this bloc copolymer is obtained thanks to a difunctionnal initiator that initiates the polymerization of the L-lactide in a first step. This polylactide first bloc has an end-group that can initiate the polymerization of the N-carboxyanhydride of benzyl L-glutamate. So we synthesize in a second step the hydrophobic bloc copolymer and we unprotect the acidic functions of the second bloc to yield the amphiphilic bloc copolymer.
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Contributor : Sylvain Caillol <>
Submitted on : Tuesday, March 16, 2004 - 9:32:54 AM
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Sylvain Caillol. Synthèse et caractérisation de nouveaux copolymères potentiellement autoassociatifs. Matériaux. Université Sciences et Technologies - Bordeaux I, 2002. Français. ⟨tel-00005354⟩

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