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Mise en oeuvre de méthodes nucléaires et de diffraction pour l'analyse de la structure de l'hydroxyapatite dopée et des transferts d'éléments métalliques à partir de biomateriaux implantés in vivo

Abstract : The metallic prostheses coated or not by biomaterials are widely used in orthopaedic surgery. The becoming of these implants are studied, particularly the degradation which can induce metallic elements transfer in adjacent tissues. The synthetic hydroxyapatite, used as filled biomaterials, resorbe fastly when it is doped with zinc as pure HAP or doped with manganese. The improve is due to biology or physico­chemistry factor. Analyses by neutron activation, ICP/AES, X­ray diffraction and infrared spectroscopy have been realised and show that these hydroxyapatites have the same composition and the same structure as pure apatite. The location of zinc in the crystalline structure of apatite has been determine by EXAFS (Extended X­ray Fine Structrure). The association of these results shows that the addition of zinc in the apatite induces a local deformation of the structure that may allow the release of this element in the organism and favours the resorption of the hydroxyapatite. Despite the progress, all metallic prostheses implant in organism induce corrosion or exchange with tissue that can produce a loosening of the prostheses. The biomaterials used to fix the implant do not stop the migration of the metallic element toward adjacent tissues. Post­mortem and surgical tissues taken off around implants were studied by PIXE (Particle Induced X­ray Emission) in order to locate and evaluate qualitatively and quantitatively the contamination with an analytical method that we have developed. The analysis by transmission electronic microscopy (TEM) shows the nature and the form of the released element. Used of nuclear and diffraction method to analyse the structure of the hydroxyapatite doped with zinc and the transfer of metallic element released by biomaterials implanted ``in vivo''.
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https://tel.archives-ouvertes.fr/tel-00001081
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Submitted on : Friday, February 1, 2002 - 10:02:07 AM
Last modification on : Thursday, January 30, 2020 - 2:24:03 PM
Long-term archiving on: : Friday, April 2, 2010 - 7:51:00 PM

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  • HAL Id : tel-00001081, version 1

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Emmanuelle Chassot. Mise en oeuvre de méthodes nucléaires et de diffraction pour l'analyse de la structure de l'hydroxyapatite dopée et des transferts d'éléments métalliques à partir de biomateriaux implantés in vivo. Physique des Hautes Energies - Expérience [hep-ex]. Université Blaise Pascal - Clermont-Ferrand II, 2001. Français. ⟨tel-00001081⟩

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