Détection et validation de marqueurs génétiques impliqués dans la qualité de la viande bovine.

Abstract : Without routine measure of sensory meat quality, breeders and breeding companies wondered how taking advantage of the genetic variability of these traits at the molecular level. The purpose of the PHD was to cover all researches related to association studies between genetic polymorphisms and phenotypes recorded in the Qualvigène program. The aim is to offer breeders and breeding companies a set of genetic markers as selection criteria. Some SNP located in candidate genes were genotyped among 3,349 young bulls of the program (1,114 in the Charolais breed, 1,254 in the Limousin breed and 981 in the Blonde breed) but also among the 114 sires and most of the dams. In the literature and in functional genomic studies at INRA, these genes were shown to be associated with meat tenderness, marbling or growth. Association studies were performed for the traits of interest. Microsatellites have been used to perform a genome scan for 6 families among the Limousin and Blonde d'Aquitaine breeds in order to find chromosomal regions of interest. In 2010, the "Bovine SNP50®" Illumina high density chip was used in the Qualvigène program to fine-map QTL for meat quality. First results in the Blonde d'Aquitaine breed are available. Some QTL regions already detected by microsatellites were confirmed and more precisely located, while new ones were also located. Following this work, looking for causal mutations should lead to the implementation of a test kit to help targeting animals with a higher genetic merit for meat quality.
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Submitted on : Monday, May 2, 2011 - 3:51:31 PM
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  • HAL Id : pastel-00589871, version 1

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Sophie Allais. Détection et validation de marqueurs génétiques impliqués dans la qualité de la viande bovine.. Génétique animale. AgroParisTech, 2011. Français. ⟨NNT : 2011AGPT0012⟩. ⟨pastel-00589871⟩

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