Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly †

Lin-Chiang Sherlock Huang (1, 2) , Dao Le (1, 3, 4) , I-Lun Hsiao (1, 5) , Susanne Fritsch-Decker (1) , Christian Hald (1) , Su-Ching Huang (6) , Jen-Kun Chen (6) , Jih Ru Hwu (2) , Carsten Weiss (1) , Min-Hua Hsu (7) , Guillaume Delaittre (1, 8)

1 KIT - Karlsruhe Institute of Technology
2 NTHU - National Tsing Hua University [Hsinchu]
3 IPCM - Institut Parisien de Chimie Moléculaire
4 LCP - Chimie des polymères
5 Taipei Medical University
6 NHRI - National Health Research Institutes [Taiwan]
7 NCUE - National Changhua University of Education
8 University of Wuppertal

Core–shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy.

Domaines: Chimie

Lin-Chiang Sherlock Huang, Dao Le, I-Lun Hsiao, Susanne Fritsch-Decker, Christian Hald, et al.. Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly †. Polymer Chemistry, 2020, 12 (1), pp.50-56. ⟨10.1039/d0py00710b⟩. ⟨hal-03145906⟩