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HFIP-Promoted Substitution in the Ferrocene Series: Smooth Approach towards Original Catalysts

Abstract : Pseudo-benzylic substitution is an important reaction in the ferrocene series, especially to obtain ligands for catalysis. Herein, we described new reactions conditions, using fluorinated alcohols as both solvent and promoter, able to deliver iodoferrocene derivatives faster than using classical solvents. Various N, O, P and C-nucleophiles were found compatible with this transformation which occurs with full retention of stereochemistry. Original P,N-ligands were prepared by using iodine/lithium exchange-chlorophoshine trapping sequences, and their properties were evaluated in Suzuki-Miyaura and Buchwald-Hartwig coupling as well as in ketone alpha-arylation reaction.
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https://hal.archives-ouvertes.fr/hal-03367746
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Friday, October 15, 2021 - 3:09:22 PM
Last modification on : Sunday, December 5, 2021 - 6:42:03 PM

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William Erb, Victor Carre, Thierry Roisnel. HFIP-Promoted Substitution in the Ferrocene Series: Smooth Approach towards Original Catalysts. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2021, ⟨10.1002/ejoc.202100824⟩. ⟨hal-03367746⟩

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