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Études structurales et propriétés de reconnaissance d'objets auto-assemblés

Abstract : Since the 1990s, dynamic combinatorial chemistry has allowed the discovery and preparation of new synthetic receptors from simple building blocks under thermodynamic control. In this context, we have recently described a new family of dynamic para cyclophanes, the so-called dyn[n]arenes. These macrocycles, made from functionalized 1,4-bisthiophenolic building blocks, could be obtained on a gram scale from a simple purification procedure, and without any chromatography. Their synthetic accessibility allows us to study the driving forces behind their self-assembly, as well as their molecular recognition properties towards ionic guest molecules. Experimental and computational experiments were also conducted to reveal the subtle physical phenomena that are responsible for the remarkable selectivity and affinity observed between a poly-anionic dyn[4]arene and a series of a,?-alkyl-diamines. During these previous studies, we rediscovered a simple synthetic route towards a family of molecules that is unexploited so far: the dithiocins. The functionalization of these molecular objects has been explored in order to generate versatile platforms for biological applications
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Submitted on : Tuesday, June 5, 2018 - 8:36:25 AM
Last modification on : Wednesday, November 20, 2019 - 3:18:54 AM
Document(s) archivé(s) le : Thursday, September 6, 2018 - 1:25:56 PM


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  • HAL Id : tel-01807646, version 1


Emeric Jeamet. Études structurales et propriétés de reconnaissance d'objets auto-assemblés. Chimie organique. Université de Lyon, 2018. Français. ⟨NNT : 2018LYSE1024⟩. ⟨tel-01807646⟩



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