Molecular and tissue alterations of collagens in fibrosis

Abstract : The collagen network is altered in fibrotic diseases associated with extracellular matrix (ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and qualitative modifications of collagens occurring at the molecular and tissue levels in fibrosis. They result from changes in collagen expression, biosynthesis, enzymatic cross-linking and degradation by several protease families. These molecular modifications, which are mostly regulated by TGF-β, are associated with altered collagen organization at the tissue level, leading to a fibrotic signature that can be analyzed by Second Harmonic Generation (SHG) microscopy.
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Sylvie Ricard-Blum, Georges Baffet, Nathalie Théret. Molecular and tissue alterations of collagens in fibrosis. Matrix Biology, Elsevier, 2018, 68-69, pp.122-149. ⟨10.1016/j.matbio.2018.02.004⟩. ⟨hal-01808771⟩

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