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US 2011/0245478 (06/10/2011) -

Method for the synthesis of oligonucleotide derivatives

Morvan François1, Meyer Albert1, Vasseur Jean-Jacques1, Sébastien Vidal2, Jean-Pierre Cloarec3, Yann Chevolot3, Éliane Souteyrand3

Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted to the oligonucleotide with the help of a "click chemistry" reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting

1 :	IBMM - Institut des Biomolécules Max Mousseron
2 :	ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
3 :	INL - Institut des nanotechnologies de Lyon - Site d'Ecully

hal-00643521, version 1

http://hal.archives-ouvertes.fr/hal-00643521

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Contributeur : Brigitte Carles <>

Soumis le : Mardi 22 Novembre 2011, 10:45:05

Dernière modification le : Mardi 22 Novembre 2011, 11:16:41