147 articles – 175 Notices  [english version]
Fiche détaillée Articles dans des revues avec comité de lecture
Analyst 132, 5 (2007) 409-11
PCB-based integration of electrochemiluminescence detection for microfluidic systems.
Patrick Pittet1, Guo-Neng Lu, Jean-Marc Galvan1, Rosaria Ferrigno1, Loïc J Blum2, Béatrice Leca-Bouvier3

This communication presents an instrumental development based on the printed circuit board (PCB) technology to integrate electrochemiluminescence (ECL) analysis in microfluidic systems. PCB gold macro- (10 mm2) and micro- (0.09 mm2) electrodes and two ECL microfluidic devices are designed, fabricated and tested via luminol ECL detection. Potential modulation is performed between 0.7 and 0 V vs. Ag/AgCl for luminol oxidation, thus giving rise to on/off ECL responses in the presence of hydrogen peroxide. Synchronous detection is adopted to allow weak ECL signal recovery at a very low signal-to-noise ratio (SNR). The detection limit obtained with the two ECL microfluidic devices is 50 nM and 100 nM H2O2 for macroelectrodes and microelectrodes, respectively.
1 :  INL - Institut des nanotechnologies de Lyon - Site d'Ecully
2 :  ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
3 :  ICBMS - Institut de Chimie et Biochimie Moléculaire et Supramoléculaire