Multiplexed binding determination of seven glycoconjugates for Pseudomonas aeruginosa lectin I (PA-IL) using a DNA-based carbohydrate microarray.

Yann Chevolot; Jing Zhang; Albert Meyer; Alice Goudot; Sonia Rouanet; Sébastien Vidal; Gwladys Pourceau; Jean-Pierre Cloarec; Jean-Pierre Praly; Eliane Souteyrand; Jean-Jacques Vasseur; François Morvan

Article in peer-reviewed journal

Chemical Communications 47, 31 (2011) 8826-8

Multiplexed binding determination of seven glycoconjugates for Pseudomonas aeruginosa lectin I (PA-IL) using a DNA-based carbohydrate microarray.

Yann Chevolot¹, Jing Zhang², Albert Meyer³, Alice Goudot¹, Sonia Rouanet³, Sébastien Vidal⁴, Gwladys Pourceau³, Jean-Pierre Cloarec¹, Jean-Pierre Praly⁴, Eliane Souteyrand¹, Jean-Jacques Vasseur³, François Morvan³

The binding of seven multivalent glycoconjugates displaying linear or antenna-like structures and different electronic environments were evaluated towards PA-IL on a DNA-based carbohydrate microarray. The affinity can be modulated by the charge and the topology of the galactosylated derivatives.

1:	INL - Institut des nanotechnologies de Lyon - Site d'Ecully

2:	LMVI - Key Laboratory of Molecular Virology & Immunology

3:	IBMM - Institut des Biomolécules Max Mousseron

4:	ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires


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Submitted on: Thursday, 10 May 2012 11:20:08
Updated on: Thursday, 10 May 2012 11:20:08